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Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. Not like opioids, which bind to µ-opioid receptors while in the central nervous process, conolidine modulates alternate molecular targets. A Science Advances research found that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which reg… Read More

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Importantly, these receptors have been uncovered to happen to be activated by a wide array of endogenous opioids at a concentration much like that observed for activation and signaling of classical opiate receptors. Subsequently, these receptors were being found to obtain scavenging action, binding to and lowering endogenous levels of opiates readi… Read More

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